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Immunol Today. 1999 Mar;20(3):130-4.

Tissue transglutaminase: apoptosis versus autoimmunity.

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Dept of Biology, University of Rome Tor Vergata, Italy.


Autoimmune diseases are characterized by multiple autoantibodies and/or autoreactive T cells that recognize a large number of antigens. Many of these antigens undergo extensive post-translational modifications during apoptosis and act as substrates for the proapoptotic cystein proteases. Here, Mauro Piacentini and Vittorio Colizzi discuss the effects on autoimmunity produced by post-translational modifications of proteins catalysed by the proapoptotic enzyme tissue transglutaminase.

[Indexed for MEDLINE]

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