Format

Send to

Choose Destination
See comment in PubMed Commons below
Neurosci Lett. 1999 Mar 5;262(2):109-12.

Divalent cations modulate glutamate receptors in retinal horizontal cells of the perch (Perca fluviatilis).

Author information

  • 1Physiologisches Institut, Justus-Liebig-Universit├Ąt, Giessen, Germany. karl.f.schmidt@physiologie.med.uni-giessen.de

Abstract

Divalent cations had two effects on concentration-response relations of glutamate induced membrane currents recorded from retinal horizontal cells. The first effect was a reduction of maximum currents. Barium, magnesium, cobalt, nickel and an increased calcium concentration caused reductions of maximum currents between 14% and 70%. The second effect of divalent cations was related to the dopamine dependent modulation of glutamate receptors in horizontal cells. The dopamine dependent enhancement of glutamate gated currents requires the presence of divalent cations besides calcium in the extracellular solution. Without such divalent cations application of dopamine caused no increase of the maximum currents induced by glutamate, and only a slight shift of the half maximal saturation concentration was observed. Addition of magnesium or barium cations in millimolar concentration was sufficient to completely restore the dopamine dependent modulation.

PMID:
10203243
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center