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Fertil Steril. 1999 Apr;71(4):701-10.

Genetic influences on endometriosis in an Australian twin sample. sueT@qimr.edu.au.

Author information

1
Cooperative Research Centre for Discovery of Genes for Common Human Diseases, Queensland Institute of Medical Research, Brisbane, Australia. sueT@qimr.edu.au

Abstract

OBJECTIVE:

To investigate the prevalence of and twin pair concordance for endometriosis.

DESIGN:

A questionnaire survey incorporating validation.

SETTING:

An Australia-wide volunteer sample of female monozygotic (MZ) and dizygotic (DZ) twin pairs from the Australian National Health and Medical Research Council Twin Register.

PATIENT(S):

Twins were selected only on the basis of previous participation in twin research.

INTERVENTION(S):

Questionnaires were sent to 3,298 individuals. Information was requested from physicians named by consenting twins.

MAIN OUTCOME MEASURE(S):

Reported endometriosis, validated where possible by pathology or surgical report.

RESULT(S):

Three thousand ninety-six (94%) of the twins and 145 (82%) of the physicians responded to the survey. Two hundred fifteen twins reported endometriosis, for a prevalence rate of .07 among question respondents. Tetrachoric twin pair correlations for self-reported endometriosis (MZ: n = 854 and DZ: n = 493) were rMz = .46+/-.09 and rDz = .28 +/-.13. When available medical and pathology reports were included, they changed to rMz =.52 +/-.08 and rDZ = .19+/-.16, suggesting that 51% of the variance of the latent liability to endometriosis may be attributable to additive genetic influences.

CONCLUSION(S):

These findings support the hypothesis that genes influence liability to endometriosis.

PMID:
10202882
[Indexed for MEDLINE]

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