Send to

Choose Destination
Trends Cell Biol. 1999 Mar;9(3):102-7.

Signal transduction by a protease cascade.

Author information

Dept of Cell Biology, Yale University School of Medicine, New Haven, CT 06520, USA.


The dorsoventral axis of the Drosophila embryo is determined by a spatial cue generated by ovarian somatic cells. This cue is communicated to the embryo through an extracellular serine protease cascade active only on the ventral side of the embryo. Studies of the proteases and somatically expressed proteins involved in this signalling process suggest a working model for how the protease cascade is locally activated hours after the ovarian somatic cells have degenerated.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center