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Cell Death Differ. 1998 Sep;5(9):720-8.

Bacterial toxins and the Rho GTP-binding protein: what microbes teach us about cell regulation.

Author information

1
Department of Ultrastructures, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy. fiorentini@ul.net.iss.it

Abstract

In the present review activities of two bacterial toxins, Clostridium botulinum exoenzyme C3 and Escherichia coli CNF1, both acting on the GTP-binding protein Rho are analyzed. Proteins belonging to the Rho family regulate the actin cytoskeleton and act as molecular switches in a number of signal transduction pathways. C3 and CNF1 have opposite effects on Rho thus representing useful tools for studies on cell division, cell differentiation and apoptosis.

PMID:
10200530
DOI:
10.1038/sj.cdd.4400412
[Indexed for MEDLINE]
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