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Gait Posture. 1998 Mar 1;7(2):131-141.

Neural control of locomotion; The central pattern generator from cats to humans.

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Department of Medical Physics and Biophysics, K.U.N., P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands


In the last years it has become possible to regain some locomotor activity in patients suffering from an incomplete spinal cord injury (SCI) through intense training on a treadmill. The ideas behind this approach owe much to insights derived from animal studies. Many studies showed that cats with complete spinal cord transection can recover locomotor function. These observations were at the basis of the concept of the central pattern generator (CPG) located at spinal level. The evidence for such a spinal CPG in cats and primates (including man) is reviewed in part 1, with special emphasis on some very recent developments which support the view that there is a human spinal CPG for locomotion.


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