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Nihon Rinsho. 1999 Mar;57(3):590-600.

[Diabetic nephropathy--recent advances in its mechanism and treatment].

[Article in Japanese]

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Department of Medicine III, Okayama University Medical School.


The elevated glomerular filtration rate that occurs in 25 to 40 percent of insulin-dependent diabetics has been proposed as having a role in the initiation and evolution of diabetic nephropathy. We report that both enhanced NO synthesis by ecNOS in afferent arterioles and glomerular endothelial cells and increased expression of IGF-1 receptor can cause glomerular hyperfiltration, and that upregulated expression of ICAM-1 can promote the intraglomerular infiltration of mononuclear cells, which were prevented by aldose reductase inhibitor. The results of United Kingdom Prospective Diabetes Study (UKPDS) will also be discussed.

[Indexed for MEDLINE]

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