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Infect Dis Clin North Am. 1999 Mar;13(1):169-85, vii-viii.

New vaccines against tuberculosis. The status of current research.

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Department of Microbiology, Colorado State University, Fort Collins, USA.


The increasing realization that the current vaccine for tuberculosis, bacille Calmette-Guérin (BCG), is of varying effectiveness, and is less protective in adults than in children, has prompted new research for a replacement. New research has resulted in innovative approaches, including the use of sub-unit vaccines, auxotropic vaccines, DNA vaccines, and recombinant vaccines, among others. This article reviews these approaches and test results in animal models, and discusses their potential for use in humans.

[Indexed for MEDLINE]

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