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J Bacteriol. 1999 Apr;181(8):2640-2.

Cyclic AMP can decrease expression of genes subject to catabolite repression in Saccharomyces cerevisiae.

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  • 1Instituto de Investigaciones Biomédicas "Alberto Sols," CSIC-UAM, 28029 Madrid, Spain.


External cyclic AMP (cAMP) hindered the derepression of gluconeogenic enzymes in a pde2 mutant of Saccharomyces cerevisiae, but it did not prevent invertase derepression. cAMP reduced nearly 20-fold the transcription driven by upstream activation sequence (UAS1FBP1) from FBP1, encoding fructose-1,6-bisphosphatase; it decreased 2-fold the activation of transcription by UAS2FBP1. Nuclear extracts from cells derepressed in the presence of cAMP were impaired in the formation of specific UASFBP1-protein complexes in band shift experiments. cAMP does not appear to act through the repressing protein Mig1. Control of FBP1 transcription through cAMP is redundant with other regulatory mechanisms.

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