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Aust N Z J Psychiatry. 1999 Feb;33(1):84-8.

Megavitamin and dietary treatment in schizophrenia: a randomised, controlled trial.

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Palmerston Centre, Hornsby Hospital, New South Wales, Australia.



The aim of this study was to assess the efficacy of adjunctive megavitamin and dietary treatment in schizophrenia.


A random allocation double-blind, controlled comparison of dietary supplement and megavitamin treatment, and an alternative procedure was given for 5 months to 19 outpatients with a diagnosis of schizophrenia. In addition to usual follow-up, the experimental group received amounts of megavitamins based on their individual serum vitamin levels plus dietary restriction based on Radioallergosorbent (RAST) tests. The control group received 25 mg vitamin C and were prescribed substances considered allergenic from the RAST test.


Five months of treatment showed marked differences in serum levels of vitamins but no consistent self-reported symptomatic or behavioural differences between groups.


This study does not provide evidence supporting a positive relationship between regulation of levels of serum vitamins and clinical outcome in schizophrenia over 5 months.

[Indexed for MEDLINE]

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