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Nat Neurosci. 1998 Oct;1(6):487-93.

Semaphorins A and E act as antagonists of neuropilin-1 and agonists of neuropilin-2 receptors.

Author information

1
Department of Neurology, Yale University School of Medicine, New Haven, Connecticut 06520, USA.

Abstract

Neuropilin-1 (NP-1) has been identified as a necessary component of a semaphorin D (SemD) receptor that repulses dorsal root ganglion (DRG) axons during development. SemA and SemE are related to SemD and bind to NP-1, but do not repulse DRG axons. By expressing NP-1 in retinal neurons and NP-2 in DRG neurons, we demonstrate that neuropilins are sufficient to determine the functional specificity of semaphorin responsiveness. SemA and SemE block SemD binding to NP-1 and abolish SemD repulsion in axons expressing NP-1. SemA and SemE seem to have a newly discovered protein antagonist capacity at NP-1 receptors, whereas they act as agonists at receptors containing NP-2.

PMID:
10196546
DOI:
10.1038/2203
[Indexed for MEDLINE]

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