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Nat Neurosci. 1998 Oct;1(6):462-9.

Formation of intermediate-conductance calcium-activated potassium channels by interaction of Slack and Slo subunits.

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1
Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06520, USA.

Abstract

Large-conductance calcium-activated potassium channels (maxi-K channels) have an essential role in the control of excitability and secretion. Only one gene Slo is known to encode maxi-K channels, which are sensitive to both membrane potential and intracellular calcium. We have isolated a potassium channel gene called Slack that is abundantly expressed in the nervous system. Slack channels rectify outwardly with a unitary conductance of about 25-65 pS and are inhibited by intracellular calcium. However, when Slack is co-expressed with Slo, channels with pharmacological properties and single-channel conductances that do not match either Slack or Slo are formed. The Slack/Slo channels have intermediate conductances of about 60-180 pS and are activated by cytoplasmic calcium. Our findings indicate that some intermediate-conductance channels in the nervous system may result from an interaction between Slack and Slo channel subunits.

PMID:
10196543
DOI:
10.1038/2176
[Indexed for MEDLINE]
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