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Nat Neurosci. 1999 Mar;2(3):234-40.

Activation of NMDA receptors reverses desensitization of mGluR5 in native and recombinant systems.

Author information

1
Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322, USA.

Abstract

The metabotropic glutamate receptor, mGluR5, has a critical role in induction of NMDA-receptor-dependent forms of synaptic plasticity and excitotoxicity. This is likely mediated by a reciprocal positive-feedback interaction between these two glutamate receptor subtypes in which activation of mGluR5 potentiates NMDA receptor currents and NMDA receptor activation potentiates mGluR5-mediated responses. We have investigated the mechanism by which NMDA receptor activation modulates mGluR5 function and find evidence that this response is mediated by activation of a protein phosphatase and a resultant dephosphorylation of protein kinase C phosphorylation sites on mGluR5. This form of neuromodulation may be important in a number of normal and pathological processes that involve activation of the NMDA receptor.

PMID:
10195215
DOI:
10.1038/6338
[Indexed for MEDLINE]

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