Format

Send to

Choose Destination
See comment in PubMed Commons below
Nat Neurosci. 1998 Aug;1(4):290-5.

Transplantation of expanded mesencephalic precursors leads to recovery in parkinsonian rats.

Author information

  • 1Laboratory of Molecular Biology, NINDS, NIH, Bethesda, Maryland 20892, USA.

Abstract

In vitro expansion of central nervous system (CNS) precursors might overcome the limited availability of dopaminergic neurons in transplantation for Parkinson's disease, but generating dopaminergic neurons from in vitro dividing precursors has proven difficult. Here a three-dimensional cell differentiation system was used to convert precursor cells derived from E12 rat ventral mesencephalon into dopaminergic neurons. We demonstrate that CNS precursor cell populations expanded in vitro can efficiently differentiate into dopaminergic neurons, survive intrastriatal transplantation and induce functional recovery in hemiparkinsonian rats. The numerical expansion of primary CNS precursor cells is a new approach that could improve both the ethical and the technical outlook for the use of human fetal tissue in clinical transplantation.

PMID:
10195162
DOI:
10.1038/1105
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group
    Loading ...
    Support Center