Format

Send to

Choose Destination
See comment in PubMed Commons below
Nat Neurosci. 1998 Jun;1(2):124-31.

Neurite growth inhibitors restrict plasticity and functional recovery following corticospinal tract lesions.

Author information

1
Brain Research Institute, University of Z├╝rich, Switzerland. thallm@hifo.unizh.ch

Erratum in

  • Nat Neurosci 1998 Aug;1(4):329.

Abstract

Anatomical plasticity and functional recovery after lesions of the rodent corticospinal tract (CST) decrease postnatally in parallel with myelin formation. Myelin-associated neurite growth inhibitory proteins prevent regenerative fiber growth, but whether they also prevent reactive sprouting of unlesioned fibers is less clear. Here we show that after unilateral CST lesion in the adult rat brainstem, both intact and lesioned tracts show topographically appropriate sprouting after treatment with a monoclonal antibody that neutralizes these inhibitory proteins. Antibody-treated animals showed full recovery in motor and sensory tests, whereas untreated lesioned rats exhibited persistent severe deficits. Neutralization of myelin-associated neurite growth inhibitors thus restores in adults the structural plasticity and functional recovery normally found only at perinatal ages.

PMID:
10195127
DOI:
10.1038/373
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group
    Loading ...
    Support Center