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Arch Dis Child Fetal Neonatal Ed. 1998 Nov;79(3):F209-11.

Randomised controlled trial of paracetamol for heel prick pain in neonates.

Author information

1
Women's College Hospital, Department of Newborn and Developmental Paediatrics, Faculty of Medicine, University of Toronto, Ontario, Canada.

Abstract

AIM:

To evaluate the effectiveness of paracetamol in decreasing the pain from heel prick.

METHODS:

A prospective randomised double blind placebo controlled trial was conducted of 75 term neonates undergoing heel prick. Sixty to 90 minutes before the procedure neonates received paracetamol orally in a dose of 20 mg/kg (group 1) or an equal volume of placebo (group 2). Heel prick was performed in a standardised manner. Pain assessments were made using per cent facial action (brow bulge, eye squeeze, and nasolabial fold (range 0-300%) and per cent of time spent crying (range 0-100%).

RESULTS:

Thirty eight neonates were enrolled in group 1 and 37 neonates in group 2. There were no significant differences in the demographic characteristics between groups. Mean gestational age was 39 (SD 1.4) vs 39.4 (SD 1.2) weeks, p = 0.86, mean birthweight 3.45 (SD 0.45) vs 3.44 (SD 0.42) kg; p = 0.31 for groups 1 and 2, respectively. Facial action pain scores did not differ between groups (143.5 (SD 54.2)% vs 131.1 (SD 59.6)%; p = 0.38). Cry scores also did not differ (29.4 (SD 19.9)% vs 26.8 (SD 20.2)%; p = 0.60). No adverse effects were observed.

CONCLUSION:

Paracetamol is ineffective for decreasing the pain from heel prick in term neonates.

PMID:
10194994
PMCID:
PMC1720857
DOI:
10.1136/fn.79.3.f209
[Indexed for MEDLINE]
Free PMC Article

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