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Phytother Res. 1999 Mar;13(2):111-4.

Modulatory potential of Spirulina fusiformis on carcinogen metabolizing enzymes in Swiss albino mice.

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1
Department of Zoology, University of Rajasthan, Jaipur, India.

Abstract

The modulatory potential of Spirulina fusiformis was observed on the hepatic and extrahepatic carcinogen metabolizing enzymes in Swiss albino mice at a dose of 800 mg/kg b.w. given orally. A significant reduction in the hepatic cytochrome P-450 content was observed in the group treated with Spirulina in comparison with the control group. The hepatic glutathione S-transferase activity was induced significantly by Spirulina treatment. There was no change in the extrahepatic glutathione S-transferase activity after the animals were fed with Spirulina.

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