Format

Send to

Choose Destination
Br J Cancer. 1999 Mar;79(9-10):1609-12.

Inducible nitric oxide synthase (iNOS) expression may predict distant metastasis in human melanoma.

Author information

1
Department of Gynaecology and Obstetrics, University of Vienna, School of Medicine, Austria.

Erratum in

  • Br J Cancer 1999 Jun;80(8):1302.

Abstract

Expression of inducible nitric oxide synthase (iNOS) and its cellular localization was investigated in subcutaneous or lymph node metastases of human melanoma. Immunohistochemistry revealed that iNOS expression was limited to melanoma cells. In samples of patients without distant metastases, the number of iNOS+ tumour cells/total tumour cells was 55% +/- 17% (n = 12) compared with 9% +/- 8% when distant metastases of lung, liver or brain occurred within an observation period of 3 years (n = 10) (P < 0.001). Western blotting confirmed the expression of iNOS protein in select cases. Notably, iNOS is expressed in regional melanoma metastases and its expression is inversely related to the tumour's metastatic potential. Thus, iNOS expression may have predictive value for the development of distant metastases of human melanoma.

PMID:
10188914
PMCID:
PMC2362722
DOI:
10.1038/sj.bjc.6690256
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Nature Publishing Group Icon for PubMed Central
Loading ...
Support Center