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Haemostasis. 1976;5(5):285-94.

Evaluation of hypercoagulability in septic abortion.

Abstract

Soluble fibrin monomer complexes (SFMC) were determined in patients with septic abortion (body temperatures of more than 39 degree C and/or chills without apparent signs of endotoxic shock), with infected abortion, with non-infected abortion and with normal pregnancies. Quantitative gel filtration (4% agarose) of beta-alanine precipitated plasma samples yielded the relative (percent of total fibrinogen content) and absolute (mg/100 ml plasma) amount of SFMC. The relative (5.5+/-1.4%, mean+/-SD) and absolute (21.5+/-8.6 mg/100 ml) amount of SFMC was significantly increased in patients with septic abortion compared to patients with normal pregnancies or non-infected abortion (p less than 0.001). Patients with infected abortion (p less than 0.001). Patients with infected abortion already revealed increased levels of SFMC (4.3+/-1.2%, 14.2+/-6.8 mg/100 ml) though their platelet count was still unaltered (infected abortion: 221+/-47 X 10(3) platelets/mm3; septic abortion; 99+/-36 X 10(3) platelets/mm3). The use of heparin in patients with septic abortion resulted in a decrease in SFMC. Chain characterization of SFMC frequently revealed a slight degradation of the alpha-chains probably due to fibrinolytic activity in vivo; gamma-gamma dimers representing intermolecular covalent bindings were not observed. The findings are in agreement with our former assumption that patients with septic abortion have a pronounced state of hypercoagulability.

PIP:

The effect of septic abortion on plasma levels of soluble fibrin monomer complexes (SFMC) was studied by quantitative gel filtration (4% agarose) of beta-alanine precipitated plasma samples. Pregnant patients and those with infected or noninfected abortions were also studied. The relative and absolute amounts of SFMC were significantly (p less than .001) increased in cases of septic abortion compared with cases of normal pregnancy or uninfected abortion. Patients with infected abortion showed increased absolute and relative levels of SFMC, though not to the extent of septic abortion cases. However, unlike septic abortion cases, platelet count was not reduced. When heparin was used in septic abortion cases, SFMC decreased. A slight degradation of the alpha-chains of SFMC probably due to in vivo fibrinolytic activity was observed. The findings confirm that patients with septic abortion have a marked degree of hypercoagulability.

PMID:
1017723
DOI:
10.1159/000214147
[Indexed for MEDLINE]

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