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Transfus Sci. 1994 Sep;15(3):207-20.

Molecular and biological actions of cyclosporin A and FK506 on T cell development and function.

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1
Division of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.

Abstract

The microbial products cyclosporin A (CsA) and FK506 are potent immunosuppressive agents in experimental and clinical transplantation. Binding of both drugs to intracellular immunophilins results in the inhibition of calcineurin activity and the prevention of interleukin-2 gene transcription and, thus, in the inhibition of T cell receptor-dependent T cell activation. CsA and FK506 also have a profound effect on the structure and function of the thymus with disruption of positive and negative selection of T cells. These influences on thymic microenvironment and T cell ontogeny disrupt the induction or maintenance of self-tolerance (or both) and are thus of relevance to clinical transplantation immunology.

PMID:
10155542
DOI:
10.1016/0955-3886(94)90133-3
[Indexed for MEDLINE]
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