Format

Send to

Choose Destination
See comment in PubMed Commons below
Trends Pharmacol Sci. 1999 Feb;20(2):79-83.

Insight into adenosine receptor function using antisense and gene-knockout approaches.

Author information

1
Department of Molecular Pharmacology and Therapeutics, EpiGenesis Pharmaceuticals, Princeton, NJ 08543, USA.

Abstract

The extensive role of adenosine in discriminating input from the extracellular environment is effected through a series of cell membrane-spanning proteins--the adenosine A1, A2A, A2B and A3 receptors. New genetic and epigenetic tools have emerged that facilitate the elucidation of the function of these receptors with greater specificity than is generally possible with traditional antagonist drugs. These tools include antisense oligonucleotides (epigenetic) and gene 'knockin' and 'knockout' mice (genetic) and are discussed in this article by Jonathan Nyce.

PMID:
10101969
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center