Format

Send to

Choose Destination
Immunol Cell Biol. 1999 Feb;77(1):90-8.

Does HIV cause depletion of CD4+ T cells in vivo by the induction of apoptosis?

Author information

1
AIDS Pathogenesis Research Unit, Macfarlane Burnet Centre for Medical Research, National Centre for HIV Virology Research, Fairfield, Victoria, Australia. anthonyj@burnet.edu.au

Abstract

The central pathogenic feature of AIDS is the dramatic loss of CD4+ lymphocytes. Despite more than a decade of intense research, the exact mechanism by which HIV causes this is still not understood. A major model for T cell depletion, proposed originally by Ameison and Capron in a report published in 1991, is that HIV sensitizes CD4+ T cells for activation-induced apoptosis. The apoptotic model of T cell depletion is discussed, and experiments that address the questions of whether apoptosis is restricted to infected cells or 'bystander' T cells, and whether T cell apoptosis requires participation of separate HIV-infected haematopoietic cell populations, are reviewed.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center