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Can J Gastroenterol. 1999 Jan-Feb;13(1):31-6.

Intestinal permeability before and after ibuprofen in families of children with Crohn's disease.

Author information

1
Department of Pediatrics, Health Science Centre, Calgary, Alberta.

Abstract

BACKGROUND:

Members of a subset of first-degree relatives of adults with Crohn's disease have been shown to have an increased baseline intestinal permeability and/or an exaggerated increase in intestinal permeability after the administration of acetylsalicylic acid.

PURPOSE:

To determine intestinal permeability in unaffected first-degree relatives of children with Crohn's disease before and after the administration of an ibuprofen challenge.

METHODS:

Lactulose-mannitol ratios, a measure of intestinal permeability, were determined in 14 healthy control families (41 subjects) and 14 families with a child with Crohn's disease (36 relatives, 14 probands) before and after ingestion of ibuprofen. An upper reference limit was defined using the control group as mean +/- 2 SD.

RESULTS:

The proportion of healthy, first-degree relatives with an exaggerated response to ibuprofen (20%, 95% CI 7% to 33%) was significantly higher than controls (P = 0.003). The exaggerated response was more common among siblings than among parents of pediatric probands.

CONCLUSIONS:

Members of a subset of first-degree relatives of children with Crohn's disease have an exaggerated increase in intestinal permeability after ibuprofen ingestion. These findings are compatible with there being a genetic link between abnormalities of intestinal permeability and Crohn's disease.

PMID:
10099814
DOI:
10.1155/1999/457315
[Indexed for MEDLINE]

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