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Chem Biol. 1999 Apr;6(4):R91-R105.

Catalytic promiscuity and the evolution of new enzymatic activities.

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1
Department of Biochemistry, B400 Beckman Center, Stanford, CA 94305-5307, USA.

Abstract

Several contemporary enzymes catalyze alternative reactions distinct from their normal biological reactions. In some cases the alternative reaction is similar to a reaction that is efficiently catalyzed by an evolutionary related enzyme. Alternative activities could have played an important role in the diversification of enzymes by providing a duplicated gene a head start towards being captured by adaptive evolution.

PMID:
10099128
DOI:
10.1016/S1074-5521(99)80033-7
[Indexed for MEDLINE]
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