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Bioorg Med Chem Lett. 1999 Feb 22;9(4):615-8.

Homoisofagomines: chemical-enzymatic synthesis and evaluation as alpha- and beta-glucosidase inhibitors.

Author information

1
Institut für Organische Chemie, Technische Universität Berlin, Germany. paul@wap0105.chem.tu-berlin.de

Abstract

Methyl- and hydroxymethyl derivatives of the highly potent glycosidase inhibitor isofagomine are accessible via aldolase-catalyzed C-C bond formation and competitively inhibit beta-glucosidase at low micromolar concentrations.

PMID:
10098675
[Indexed for MEDLINE]

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