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Bioorg Med Chem Lett. 1999 Feb 22;9(4):589-94.

Stereoselective synthesis and receptor activity of conformationally defined retinoid X receptor selective ligands.

Author information

1
Retinoid Research, Department of Chemistry, Allergan Inc., Irvine, CA 92623, USA.

Abstract

Retinoid X Receptor (RXR) specific ligands are currently being investigated for the treatment of metabolic diseases such as type II diabetes. We report the synthesis of conformationally locked retinoids, which are potent RXR selective ligands, and the attempted synthesis of 9-cyclopropyl locked analogs of RA and 9-cis RA.

PMID:
10098670
DOI:
10.1016/s0960-894x(99)00048-7
[Indexed for MEDLINE]

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