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Trends Biochem Sci. 1999 Feb;24(2):73-6.

The role of the cell-adhesion molecule E-cadherin as a tumour-suppressor gene.

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1
Research Institute of Molecular Pathology, Vienna, Austria. christofori@nt.imp.univie.ac.at

Abstract

E-cadherin-mediated cell-cell adhesion is lost during the development of most epithelial cancers. Recent evidence indicates that the loss of E-cadherin function, besides causing loss of cell-cell adhesion, might also convey signals that actively induce tumour-cell invasion and metastasis.

PMID:
10098402
[Indexed for MEDLINE]
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