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Immunol Today. 1999 Feb;20(2):89-94.

Chemokine receptors and HIV-1: the fusion of two major research fields.

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Dept of Immunology, Berlex Biosciences, Richmond, CA 94804, USA.


Chemokines mediate their effects by binding to cell-surface receptors that belong to the seven-transmembrane-domain superfamily of proteins. Chemokine receptors have been subject to intense scrutiny following the recent discovery that several of them are co-receptors for HIV-1. Here, Richard Horuk reviews the latest developments in chemokine receptor research with a particular focus on their role as HIV-1 co-receptors.

[Indexed for MEDLINE]

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