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Yonsei Med J. 1998 Dec;39(6):520-5.

Plasmid-encoded AmpC beta-lactamases: how far have we gone 10 years after the discovery?

Author information

1
Max von Pettenkofer Institut für Hygiene und Medizinische Mikrobiologie, Ludwig-Maximilians-Universitat München, Germany. Adolf.Bauernfeind@mvp-bak.med.uni-muenchen.de

Abstract

The dogma that ampC genes are located exclusively on the chromosome was dominant until about 10 years ago. Since 1989 over 15 different plasmid-encoded AmpC beta-lactamases have been reported from several countries. Most of these enzymes evolved in two clusters. The major cluster includes several enzymes with a high similarity to CMY-2, which is the closest related chromosomal AmpC enzyme of Citrobacter freundii. A second cluster centers around CMY-1. It is less homogeneous and not closely related chromosomal AmpC enzymes. Molecular diversification by amino acid substitutions does not usually translate into a change in the resistance phenotype. At this time, CMY-2 appears to be the most prevalent and widely distributed. Further global increase of prevalence and diversity of plasmidic AmpC beta-lactamases have to be anticipated in the next millenium.

PMID:
10097678
DOI:
10.3349/ymj.1998.39.6.520
[Indexed for MEDLINE]
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