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Neuroreport. 1999 Jan 18;10(1):15-9.

OMP gene deletion causes an elevation in behavioral threshold sensitivity.

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Department of Neuroscience and Physiology and The Clinical Olfactory Research Center, SUNY Health Science Center, Syracuse, NY 13210, USA.


To characterize the behavioral consequences of OMP gene deletion on odor processing we assessed the ability of OMP-null animals to acquire an air vs odor discrimination for five odorants, and determined whether OMP-null animals differed from controls in their threshold sensitivity to the odorant propanol. On average, control and OMP-null animals did not differ in the number of testing sessions needed to achieve criterion performance on each discrimination problem (2.04 vs 1.68, respectively; t=0.83, p=0.41). However, null animals were significantly less sensitive to the odorant propanol (3.01 x 10(-8) vs 1.06 x 10(-5), respectively; t=4.09, p=0.015). These in vivo behavioral results provide support for the hypothesis that OMP plays a modulatory role in the odor detection/signal transduction process.

[Indexed for MEDLINE]

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