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Bioorg Med Chem Lett. 1999 Feb 8;9(3):443-8.

Inhibition of herpes proteases and antiviral activity of 2-substituted thieno[2,3-d]oxazinones.

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  • 1SmithKline Beecham Pharmaceuticals, New Frontiers Science Park, Harlow, Essex, UK. Richard_L_Jarvest@sbphrd.com

Abstract

Cinnamyl derivatives of thieno[2,3-d]oxazinones are mechanism-based inhibitors of the HSV-2, VZV and CMV herpes proteases which demonstrate nanomolar potency. Compounds 5 and 28 inhibit protease processing in HSV-2 infected cells with a selectivity index of at least 30.

PMID:
10091699
[PubMed - indexed for MEDLINE]

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