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Bioorg Med Chem Lett. 1999 Feb 8;9(3):313-8.

Carbohydroxamido-oxazolidines: antibacterial agents that target lipid A biosynthesis.

Author information

1
Department of Medicinal Chemistry, Merck Research Laboratories, Rahway, New Jersey 07065, USA.

Abstract

A series of carbohydroxamido-oxazolidine inhibitors of UDP-3-O-[R-3-hydroxymyristoyl]-GlcNAc deacetylase, the enzyme responsible for the second step in lipid A biosynthesis, was identified. The most potent analog L-161,240 showed an IC50 = 30 nM in the DEACET assay and displayed an MIC of 1-3 microg/mL against wild-type E. coli.

PMID:
10091675
DOI:
10.1016/s0960-894x(98)00749-5
[Indexed for MEDLINE]

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