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Cell Calcium. 1998 Nov-Dec;24(5-6):377-85.

Ca2+ and synaptic plasticity.

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Department of Anatomy, Medical School, University of Bristol, UK.


A major effort in neuroscience is directed towards understanding the roles of Ca2+ signalling in the induction of synaptic plasticity. Here, we summarize the evidence concerning Ca2+ signalling, paying particular attention to CA1 excitatory synapses, and its relationship to the induction of long-term potentiation and long-term depression. We discuss the ways in which synaptic activation can elevate Ca2+ postsynaptically and how dendritic spines may act as a Ca2+ compartment which can both isolate and integrate Ca2+ signals.

[Indexed for MEDLINE]

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