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Cell Calcium. 1998 Nov-Dec;24(5-6):345-57.

Usefulness and limitations of linear approximations to the understanding of Ca++ signals.

Author information

1
Max-Planck-Institut für biophysikalische Chemie, Göttingen, Germany. eneher@gwdg.de

Erratum in

  • Cell Calcium 1999 Mar;25(3):275.

Abstract

Simple approximations to some limiting cases of Ca++ signalling provide insight into the complex problems of buffered diffusion and of Ca++ homeostasis in the presence of buffers. Three cases are presented, where the influence of Ca++ buffers can readily be understood in the limit of small signals: the return of global cellular [Ca++] following a short stimulus in a 'Single Compartment', buffered diffusion along a cylindrical axon in the 'Rapid Buffer Approximation', and nonequilibrium microdomains of elevated [Ca++] in the immediate vicinity of open Ca++ channels.

PMID:
10091004
DOI:
10.1016/s0143-4160(98)90058-6
[Indexed for MEDLINE]

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