Progress report: the Arizona phase III study of the effect of wheat bran fiber on recurrence of adenomatous colon polyps

D L Earnest; R E Sampliner; D J Roe; B van Leeuwen; J Guillen; M Reid; M E Martinez; J R Marshall; D S Alberts

doi:10.1016/s0002-9343(99)00003-0

Progress report: the Arizona phase III study of the effect of wheat bran fiber on recurrence of adenomatous colon polyps

Am J Med. 1999 Jan 25;106(1A):43S-45S. doi: 10.1016/s0002-9343(99)00003-0.

Authors

D L Earnest¹, R E Sampliner, D J Roe, B van Leeuwen, J Guillen, M Reid, M E Martinez, J R Marshall, D S Alberts

Affiliation

¹ Department of Medicine, University of Arizona Health Sciences Center, and the VA Medical Center, Tucson 85724-5028, USA.

PMID: 10089115
DOI: 10.1016/s0002-9343(99)00003-0

Abstract

A double-blind, placebo-controlled Phase III cancer prevention trial in subjects with previous resection of adenomatous colon polyps is nearing completion. The study's primary objective is to evaluate the effects of daily dietary supplementation with large (13.5 g/day) versus small (2.0 g/day) doses of wheat bran fiber for 3 years. A summary of the study design and a progress report are presented.

Publication types

Clinical Trial
Clinical Trial, Phase III
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Adenomatous Polyposis Coli / diet therapy*
Adenomatous Polyposis Coli / etiology
Adenomatous Polyposis Coli / metabolism
Adenomatous Polyposis Coli / prevention & control*
Arizona
Bile Acids and Salts / metabolism
Dietary Fiber / administration & dosage*
Double-Blind Method
Humans
Research Design

Substances

Bile Acids and Salts
Dietary Fiber

Abstract

Publication types

MeSH terms

Substances

Grants and funding