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Cancer Genet Cytogenet. 1999 Mar;109(2):119-22.

Ring chromosomes in a malignant mesenchymoma.

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Department of Human Genetics, University Hospital, Nijmegen, The Netherlands.


We report, for the first time, the cytogenetic and molecular genetic constitution of a human mesenchymoma. As in several other soft tissue sarcomas, supernumerary ring and rod-shaped marker chromosomes were observed next to an otherwise normal diploid karyotype. Comparative genomic in situ hybridization and whole chromosome painting experiments revealed that chromosome 1q21-q25 and 12q14-q15 sequences were amplified, and that these sequences resided on the supernumerary marker chromosomes. We assume that, in this malignant mesenchymoma, the observed chromosomal anomalies may be associated with its well differentiated liposarcomatous component.

[Indexed for MEDLINE]

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