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Trends Biochem Sci. 1999 Jan;24(1):26-33.

Is protein folding hierarchic? I. Local structure and peptide folding.

Author information

1
Dept of Biochemistry, Beckman Center, Stanford University Medical Center School of Medicine, CA 94305-5307, USA.

Abstract

The folding reactions of some small proteins show clear evidence of a hierarchic process, whereas others, lacking detectable intermediates, do not. Nevertheless, we argue that both classes fold hierarchically and that folding begins locally. If this is the case, then the secondary structure of a protein is determined largely by local sequence information. Experimental data and theoretical considerations support this argument. Part I of this article reviews the relationship between secondary structures in proteins and their counterparts in peptides.

PMID:
10087919
DOI:
10.1016/s0968-0004(98)01346-2
[Indexed for MEDLINE]

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