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Trends Biochem Sci. 1999 Jan;24(1):22-5.

Dealing with energy demand: the AMP-activated protein kinase.

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St Vincent's Institute of Medical Research, Fitzroy, Victoria.


The AMP-activated protein kinase (AMPK) is a member of a metabolite-sensing protein kinase family that is found in all eukaryotes. AMPK activity is regulated by vigorous exercise, nutrient starvation and ischemia/hypoxia, and modulates many aspects of mammalian cell metabolism. The AMPK yeast homolog, Snf1p, plays a major role in adaption to glucose deprivation. In mammals, AMPK also has diverse roles that extend from energy metabolism through to transcriptional control.

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