Format

Send to

Choose Destination
See comment in PubMed Commons below
Trends Biochem Sci. 1999 Jan;24(1):22-5.

Dealing with energy demand: the AMP-activated protein kinase.

Author information

1
St Vincent's Institute of Medical Research, Fitzroy, Victoria. b.kemp@medicine.unimelb.edu.au

Abstract

The AMP-activated protein kinase (AMPK) is a member of a metabolite-sensing protein kinase family that is found in all eukaryotes. AMPK activity is regulated by vigorous exercise, nutrient starvation and ischemia/hypoxia, and modulates many aspects of mammalian cell metabolism. The AMPK yeast homolog, Snf1p, plays a major role in adaption to glucose deprivation. In mammals, AMPK also has diverse roles that extend from energy metabolism through to transcriptional control.

PMID:
10087918
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center