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Trends Cell Biol. 1999 Jan;9(1):28-35.

Bi-cycling the furin pathway: from TGN localization to pathogen activation and embryogenesis.

Author information

1
Vollum Institute, Oregon Health Sciences University, Portland 97201, USA.

Abstract

Furin is a secretory pathway endoprotease that catalyses the maturation of a strikingly diverse group of proprotein substrates, ranging from growth factors and receptors to pathogen proteins, in multiple compartments within the trans-Golgi network (TGN)/endosomal system. This review focuses on recent developments in the biochemistry and cell biology of the endoprotease, including the mechanism of TGN localization, phosphorylation-dependent regulation of protein traffic, and novel insights into early embryogenesis, extracellular matrix formation and pathogen virulence.

PMID:
10087614
DOI:
10.1016/s0962-8924(98)01382-8
[Indexed for MEDLINE]

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