Send to

Choose Destination
Trends Cell Biol. 1999 Jan;9(1):28-35.

Bi-cycling the furin pathway: from TGN localization to pathogen activation and embryogenesis.

Author information

Vollum Institute, Oregon Health Sciences University, Portland 97201, USA.


Furin is a secretory pathway endoprotease that catalyses the maturation of a strikingly diverse group of proprotein substrates, ranging from growth factors and receptors to pathogen proteins, in multiple compartments within the trans-Golgi network (TGN)/endosomal system. This review focuses on recent developments in the biochemistry and cell biology of the endoprotease, including the mechanism of TGN localization, phosphorylation-dependent regulation of protein traffic, and novel insights into early embryogenesis, extracellular matrix formation and pathogen virulence.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center