Format

Send to

Choose Destination
Trends Cell Biol. 1999 Jan;9(1):11-4.

Putting E. coli on a pedestal: a unique system to study signal transduction and the actin cytoskeleton.

Author information

1
Dept of Biochemistry, University of British Columbia, Vancouver, Canada.

Abstract

Enteropathogenic Escherichia coli (EPEC) subverts host signalling pathways and the cytoskeleton during infection, resulting in disease characterized by diarrhoea. Recent studies have revolutionized our understanding of the infection process by showing that this bacterium inserts its own receptor into the plasma membrane overlying the host actin cytoskeleton. The reorganized actin forms a pedestal-like structure with the bacterium at the tip. This review discusses the mechanism of infection and pedestal formation and how this system might be a powerful tool for studying actin dynamics at the plasma membrane.

PMID:
10087611
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center