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Trends Biotechnol. 1999 Feb;17(2):78-83.

The in vivo delivery of heterologous proteins by microencapsulated recombinant cells.

Author information

1
Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada. changp@fhs.mcmaster.ca

Abstract

The microencapsulation of recombinant cells is a novel and potentially cost-effective method of heterologous protein delivery. A 'universal' cell line, genetically modified to secrete any desired protein, is immunologically protected from tissue rejection by enclosure in microcapsules. The microcapsule can then be implanted in different recipients to deliver recombinant proteins in vivo.

PMID:
10087608
DOI:
10.1016/s0167-7799(98)01250-5
[Indexed for MEDLINE]

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