Format

Send to

Choose Destination
Am J Gastroenterol. 1999 Mar;94(3):744-50.

Lectin binding to human colonocytes is predictive of colonic neoplasia.

Author information

1
Department of Medicine, Womack Army Medical Center, Ft. Bragg, North Carolina, USA.

Abstract

OBJECTIVE:

The aim of this study was to determine whether lectin binding to exfoliated human colonocytes could be used as a noninvasive test for colorectal polyps or cancer.

METHODS:

Colonocytes were harvested from 31 patients (10 controls, 10 with adenomatous polyps, and 11 with cancer), incubated with a panel of fluorescent-labeled lectins, and assayed by flow cytometry.

RESULTS:

The lectins jacalin (JAC) and wheat germ agglutinin (WGA) were useful in predicting the presence of a colorectal neoplasm (p = 0.0018 for JAC and p = 0.0099 for WGA). For JAC, sensitivity reached 81% with a specificity of 80%, and for WGA the sensitivity and specificity were both 75%.

CONCLUSIONS:

Lectin binding to human colonocytes can predict the presence of malignant and premalignant lesions of the colon, and has potential as a noninvasive screening tool for colorectal neoplasms.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wolters Kluwer
Loading ...
Support Center