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JAMA. 1999 Mar 17;281(11):1014-8.

Hepatotoxicity associated with isoniazid preventive therapy: a 7-year survey from a public health tuberculosis clinic.

Author information

1
Seattle-King County Department of Public Health, Department of Medicine, University of Washington, 98104, USA. charles.nolan@metrokc.gov

Abstract

CONTEXT:

Isoniazid preventive therapy for latent tuberculosis (TB) infection has been debated because of the risk of hepatotoxicity. The frequency of hepatotoxicity was 0.5% to 2.0% in early studies but may have changed with new criteria for diagnosis and patient selection.

OBJECTIVE:

To determine the rate of isoniazid hepatotoxicity in patients managed according to current guidelines and practice standards.

DESIGN:

Prospective cohort study.

SETTING:

A public health clinic operated by the TB control program of a city-county public health agency.

PATIENTS:

A total of 11141 consecutive patients who started a regimen of isoniazid preventive therapy for latent TB infection from January 1989 through December 1995.

MAIN OUTCOME MEASURES:

The rate of developing symptoms and signs of hepatotoxicity among all persons starting isoniazid preventive therapy, among all those completing therapy, and by age, sex, and race.

RESULTS:

Eleven patients (0.10% of those starting, and 0.15% of those completing treatment) had hepatotoxic reactions to isoniazid during preventive treatment. The rate of hepatotoxicity in persons receiving preventive therapy increased with increasing age (chi2 for linear trend = 5.22, P=.02) and there were trends toward increased rates in women (odds ratio [OR], 3.30; 95% confidence interval [CI], 0.87-12.45; chi2 = 3.28; P=.07) and in whites (OR, 2.60; 95% CI, 0.75-8.95; chi2 = 3.08; P=.08).

CONCLUSIONS:

The rate of isoniazid hepatotoxicity during clinically monitored preventive therapy was lower than has been reported previously. Clinicians should have greater confidence in the safety of isoniazid preventive therapy.

PMID:
10086436
[Indexed for MEDLINE]

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