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Vox Sang. 1999;76(2):120-3.

Pan-reactive platelet antibodies in post-transfusion purpura.

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  • 1Department of Clinical Immunology, Glostrup Hospital, Denmark.

Abstract

BACKGROUND AND OBJECTIVES:

The mechanism for the destruction of a patient's own platelets in post-transfusion purpura (PTP) is unknown. In order to test the hypothesis that the destruction of autologous platelets in PTP is related to the presence of platelet antibodies with pan-reactivity, we investigated sera from patients with PTP.

MATERIALS AND METHODS:

Sera from 12 patients with PTP were investigated for platelet antibodies by platelet-ELISA and monoclonal antibody-specific immobilization of platelet antigen assay.

RESULTS:

During the thrombocytopenic phase, antibodies of IgG and IgM classes with pan-specificity against platelet GPIIb-IIIa, GPIb-IX and GPIa-IIa were found together with HPA alloantibodies. After recovery, the pan-specific antibodies disappeared or the extent of reactivity diminished, whereas the IgG HPA alloantibodies persisted.

CONCLUSION:

These findings provide evidence that transient panreactive antibodies may be responsible for the autologous platelet destruction in PTP.

PMID:
10085529
DOI:
31031
[PubMed - indexed for MEDLINE]
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