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Infect Immun. 1999 Apr;67(4):2019-21.

Alkaline conditions accelerate polymorphonuclear leukocyte apoptosis in vitro.

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1
Sections of Periodontology, College of Dentistry, The Ohio State University Health Sciences Center, Columbus, Ohio 43210, USA.

Abstract

Apoptosis was monitored in polymorphonuclear leukocytes (PMNs) cultured under mildly acidic, neutral, and alkaline conditions. Within 3 h, 9.0% of the PMNs underwent apoptosis at pH 6.7, as did 12% at pH 7.2, 38% at pH 7.7, and 60% at pH 8.2. Inhibitors of serine proteases, caspase-1, or caspase-3 significantly inhibited PMN apoptosis at pH 8.2, suggesting an involvement by these enzymes.

PMID:
10085052
PMCID:
PMC96562
[Indexed for MEDLINE]
Free PMC Article
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