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J Clin Endocrinol Metab. 1999 Mar;84(3):856-62.

Genetic control of 24-hour growth hormone secretion in man: a twin study.

Author information

1
Department of Psychiatry, Erasme Hospital, Université Libre de Bruxelles, Brussels, Belgium. jmendlew@ulb.ac.be

Abstract

The aim of this study was to delineate the contributions of genetic and environmental factors in the regulation of the 24-h GH secretion. The 24-h profile of plasma GH was obtained at 15-min intervals in 10 pairs of monozygotic and 9 pairs of dizygotic normal male twins, aged 16-34 yr. Sleep was polygraphically monitored. Significant pulses of GH secretion were identified using a modification of the computer algorithm ULTRA. For each significant pulse, the amount of GH secreted was calculated by deconvolution. A procedure specially developed for twin studies was used to partition the variance of investigated parameters into genetic and environmental contributions. A major genetic effect was evidenced on GH secretion during wakefulness (with a heritability estimate of 0.74) and, to a lesser extent, on the 24-h GH secretion. Significant genetic influences were also identified for slow wave sleep and height. These data demonstrate that human GH secretion in young adulthood is markedly dependent on genetic factors.

PMID:
10084561
DOI:
10.1210/jcem.84.3.5525
[Indexed for MEDLINE]

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