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Science. 1999 Mar 19;283(5409):1923-7.

Rapid dendritic morphogenesis in CA1 hippocampal dendrites induced by synaptic activity.

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1
Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.

Abstract

Activity shapes the structure of neurons and their circuits. Two-photon imaging of CA1 neurons expressing enhanced green fluorescent protein in developing hippocampal slices from rat brains was used to characterize dendritic morphogenesis in response to synaptic activity. High-frequency focal synaptic stimulation induced a period (longer than 30 minutes) of enhanced growth of small filopodia-like protrusions (typically less than 5 micrometers long). Synaptically evoked growth was long-lasting and localized to dendritic regions close (less than 50 micrometers) to the stimulating electrode and was prevented by blockade of N-methyl-D-aspartate receptors. Thus, synaptic activation can produce rapid input-specific changes in dendritic structure. Such persistent structural changes could contribute to the development of neural circuitry.

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PMID:
10082466
[Indexed for MEDLINE]
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