The results of surgical treatment of 293 patients with postbulbar duodenal ulcers (PBU) have been analysed. It was established that PBU in the majority of cases are associated with several complications of the ulcer, the main of which being penetration of the ulcer into the pancreatic head. Comparing the results of resections of the stomach and organ-saving procedures in PBU, the author suggests that organ-saving methods in combination with vagotomy have some advantages over resectional methods.