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Trends Microbiol. 1999 Feb;7(2):67-71.

Macrophages in host defense against Histoplasma capsulatum.

Author information

1
Division of Infectious Diseases, University of Cincinnati College of Medicine, OH 45267-0560, USA. newmansl@email.uc.edu

Abstract

Macrophages function in both innate and cell-mediated immunity in host defense against pathogenic fungi. They initially serve as a protected environment in which the primary fungal pathogen Histoplasma capsulatum multiplies and disseminates from the lung to other organs. Upon induction of cell-mediated immunity, cytokines activate macrophages to destroy the yeasts and thus remove them from the host.

PMID:
10081083
DOI:
10.1016/s0966-842x(98)01431-0
[Indexed for MEDLINE]

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